Photodynamics of Subependymal Giant Cell Astrocytoma (SEGA) with 5-Aminolevulinic Acid (5-ALA/Gliolan©)

Abstract AIMS 5-ALA (Gliolan©) is a valuable surgical tool used predominantly in high grade tumours, which utilises tissue fluorescence to improve the visualisation of brain-tumour interface. This ensures safe maximal resection, while preserving healthy brain. While Gliolan© use low tumours has previously been reported with variable results, reports its and success context SEGA are extremely rare. report highlights patient presenting Subependymal Giant Cell Astrocytoma (in background tuberous sclerosis), facilitating resection eloquent tissue. METHOD Tumour was performed pre-operative DTI-fiber tracking mapping. A transsulcal minimal invasive parafascicular approach (tsMIPS) carried out assistance NICO BrainPath© tubular retractor system (60x13.5), neuronaviagtion, Gliolan©, intra-operative neuro monitoring (IONM), ultrasound guidance RESULTS The tumour found have both bright pale cystic solid components respectively. Resection limited soft component only, as showed anatomical attachment subgenual area fornix. No perceived at end resection. made good recovery no post-operative deficits. Histopathology confirmed subependymal giant cell astrocytoma (SEGA, WHO I). adjuvant treatment required CONCLUSION suggests may be beneficial SEGAs. Further studies technological advances photodynamics, imaging, mapping helpful fully evaluate efficacy SEGAs other low-grade tumours.